International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 2
2013 (April - June)
EVALUATION OF SERUM URIC ACID AND LIPID PROFILE IN GESTATIONAL HYPERTENSION.
Gestational hypertension (GH) is one of the causes for increased maternal morbidity and mortality and leads to 15% of preterm births. Dyslipidaemia and hyperuricemia are suggested to have pathophysiological role. 100 women with GH and 100 normotensive pregnant women were included in the study. Serum Glucose lessThan b greaterThan , lessThan /b greaterThan lipid profile and uric acid were estimated by standard enzymatic methods. In our study the total cholesterol, triglycerides, LDL-C, VLDL-C and uric acid were significantly elevated and HDL-C was significantly decreased in GH group compared to control (p lessThan 0.0001). Uric acid showed significant positive correlation with systolic blood pressure, TGL, and TGL/HDL (r = 0.287, p lessThan 0.01; r = 0.551, p lessThan 0.001; r = 0.429, p lessThan 0.001 respectively) and negative correlation with HDL/VLDL (r = -0.415, p lessThan 0.001).TGL showed significant positive correlation with diastolic blood pressure (r = 313, p = 0.001); uric acid(r = 0.551, p lessThan 0.001), TGL/HDL (r = 0.762, p lessThan 0.001) and negative correlation with HDL/VLDL (r = -0.701, p lessThan 0.001). Lipid profile and serum uric acid measurements in the early 2 lessThan sup greaterThan nd lessThan /sup greaterThan trimester can be suggested as cost-effective markers in the prevention of the complications of GH.
DR. P.JOSEPHINE LATHA AND DR. S.GANESAN
Gestational hypertension, Lipid profile, Dyslipidaemia, Uric acid, Preeclampsia.
496-502