10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The present study was aimed to assess the IL-6 G174C gene polymorphism, metabolic risk markers, hyperandrogenemia and Insulin Resistance in PCOS women. Total 439 women were enrolled. Circulating IL-6, Insulin, lipid profile, hyperandrogenemic parameters were measured in the groups and subgroups, insulin resistance was calculated and IL-6- G174C genotyping was done. The observation shows significantly high frequency distribution of mutant genotype CC+GC (p= lessThan 0.001; OR=2.76, 95%CI=1.69-4.49) and mutant C allele (p= lessThan 0.001, OR=1.75, 95%CI=1.34-2.28) in PCOS women compared to non-PCOS group and in metabolic subgroups compared to non metabolic subgroups. In conclusion, the mutant C allele and mutant genotype of IL-6 promoter gene polymorphism were significantly associated with PCOS, high circulatory IL-6 and metabolic risk markers irrespective of presence or absence of PCOS. Women having mutant genotype of IL-6 gene and high circulatory IL-6, central obesity, Insulin resistance and dyslipidemia are more prone for development of cardio metabolic diseases. GUPTA VANI, GUPTA VANDANA, KUMAR SANDEEP, SRIVASTAVA NIDHI AND PRADEEP YASHODHARA Metabolic risk markers, Polycystic ovary syndrome, Insulin resistance, IL-6 promoter gene polymorphism, Circulating IL-6. 420-433