10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The aim of the present study is to evaluate the lessThan i greaterThan in vivo lessThan /i greaterThan anticancer activity of ethanolic extract of F lessThan i greaterThan icus glomerata lessThan /i greaterThan on DMBA induced mammary carcinoma in rats. lessThan i greaterThan Ficus glomerata lessThan /i greaterThan Roxb is an indigenous medicinal plant, belonging to the family Moraceae. It is largely used in herbal and herbo-mineral preparation to treat cancer, cardiovascular diseases, asthma, viral hepatitis and diabetes. DMBA at a dose of 20mg/kg body weight (gastric intubation) significantly elevated the xenobiotic markers such as cytochrome P lessThan sub greaterThan 450 lessThan /sub greaterThan reductase and cytochrome b lessThan sub greaterThan 5 lessThan /sub greaterThan reductase in group (II) rats. On the treatments with the ethanolic extract of lessThan i greaterThan Ficus glomerata lessThan /i greaterThan leaf extract (150 mg/kg bw p.o.) significantly decreased these activities in a group (III) rats when compared to DMBA induced rats, which confirmed its anticancer potential. The TCA cycle marker enzymes namely succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase and NADH dehydrogenase were significantly decreased by DMBA induction in group (II) rats, these enzyme levels were reverted to near normal by the supplementation of lessThan i greaterThan F. glomerata lessThan /i greaterThan in group (III) rats. The results of our present study clearly showed that the lessThan i greaterThan F. glomerata lessThan /i greaterThan possess significant anticancer activity. V.DHANA RANGESH KUMAR, G.JEYANTHI AND K.GURUSAMY Ficus glomerata, cytotoxic, 7, 12-dimethylbenz (a)anthracene (DMBA), cytochrome P450 reductase, cytochrome b5 reductase 142-149