10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The acute toxicity study of lessThan i greaterThan Ficus racemosa lessThan /i greaterThan and lessThan i greaterThan Cissampelos pareira lessThan /i greaterThan , was investigated. The acute toxicity test of the extracts was determined according to the OECD guidelines No. 420 (Organization for Economic Co-operation and Development). Female Wistar rats (150–180 g) were used for this study. A starting dose of 2000 mg/kg (P.O.) of the test samples were given to various extract groups containing 5 rats in each group. Rats were randomly selected for the study and tail marked to provide individual identifications. Rats were observed immediately after dosing during first 30 minutes, periodically during the first 24 hours, with special attention given during first 4 hours, and daily thereafter for 14 days (OECD guidelines, 2001). During the first four hours rats were tested for following various responses like behavioral response,neurological response and autonomic response and were accessed by their respective parameters.All the animals were found healthy and the extracts were found to be safe up to a dose of 2000 mg/kg. CHOUDHURY PRADEEP KUMAR AND JADHAV SACHIN Acute toxicity, Cissampelos pareira, Ficus racemosa, Methanolic extracts, Wistar Rats. 1050-1055