10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The antidiabetic properties of aqueous extract of lessThan i greaterThan Smilax perfoliata lessThan /i greaterThan (Smilacaceae) leaves on alloxan-induced diabetic mice is reported. The hypoglycemic activity, antihyperglycemic activity and Oral Glucose Tolerance Tests (OGTT) demonstrated that the extract possesses blood glucose lowering potential. Further, the extract treated diabetic mice displayed an overall improvement in the lipid profile and liver enzymes (AST and ALT) activity. lessThan i greaterThan Smilax perfoliata lessThan /i greaterThan extract also exhibited DPPH radical scavenging activity lessThan i greaterThan in vitro lessThan /i greaterThan . Total polyphenols, flavonoids, protein and carbohydrate content were assayed and found to be 63.45 mg GAE/g dry weight, 34.06 mg Rutin equivalents/g dry weight, 0.39 % and 40.68 %, respectively. The results from the experiments conducted show that aqueous extract of lessThan i greaterThan Smilax perfoliata lessThan /i greaterThan displays potent antidiabetic and hypolipidemic activity and merit its inclusion as a natural product with therapeutic potential. DONKUPAR SYIEM AND PHIBANGIPAN WARJRI Smilax perfoliata, antidiabetic, antihyperglycemic, hypolipidemic, AST, ALT. 945-955