10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) lessThan i greaterThan Phyllanthus amarus lessThan /i greaterThan Schum. & Thonn. is an important plant of Indian Ayurvedic system of medicine and its various parts were used traditionally for the treatment of problems related to stomach, wounds, liver and spleen. The objective of this study was to evaluate the anti-inflammatory activity of hexane (PAHE), ethyl acetate (PAEA), methanolic (PAME) extracts and isolated lignans (phyllanthin (PAPH) & hypophyllanthin (PAHP)) of lessThan i greaterThan P.amarus lessThan /i greaterThan aerial parts by using carrageenan induced hind-paw-oedema model. The tested extracts (125, 250 & 500mg/kg b.w) and lignans (1.3x10 lessThan sup greaterThan -5 lessThan /sup greaterThan & 2.6x10 lessThan sup greaterThan -5 lessThan /sup greaterThan moles/kg b.w) produced dose dependent significant reduction (p lessThan 0.05–0.001) in carrageenan-induced rat paw oedema. The standard drug, Indomethacin at dose 1.3×10 lessThan sup greaterThan -5 lessThan /sup greaterThan moles/kg b.w reduced oedema by 62.01±0.22% and the total (AUC) paw oedema by 69.09±0.15% respectively. The results suggested that the tested extracts and lignans possess lessThan i greaterThan in vivo lessThan /i greaterThan anti-inflammatory activity and the exhibited activity was comparable with the standard drug Indomethacin. P.MADHU KIRAN AND B.GANGA RAO Phyllanthus amarus, lignans, carrageenan and anti-inflammatory activity. 803-808