10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The objective of the present study appraised the hepatoprotective activity of methanolic extract of lessThan i greaterThan Melia azedarach. L lessThan /i greaterThan leaves on Wistar rats. The Methanolic extracts of lessThan i greaterThan Melia azedarach. L lessThan /i greaterThan (200mg & 500mg/kg,b.w,p.o) was administered respectively to the animals which were treated with carbon tetrachloride. Its effects on biochemical parameters were compared with standard drug silymarin (100mg/kg,b.w p.o). lessThan i greaterThan Melia azedarach. L lessThan /i greaterThan showed prominent reduction of serum enzymes-AST, ALT, ALP, TP & Bilirubin (Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase, Total Protein & Total bilirubin) when compared to the control rats. The hepatoprotective effect of lessThan i greaterThan Melia azedarach. L lessThan /i greaterThan was comparable with the standard drug Silymarin. It was confirmed through histopathological study. The effect of extracts 500mg/kg was almost equal to that of standard drug Silyymarin. aaa,DR.A.SUMATHI Melia azedarach. L,carbon tetrachloride,hepatoprotective,Silymarin. 755-760