10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) The anti-ulcer activity of the aqueous extract of lessThan i greaterThan Portulaca lessThan /i greaterThan lessThan i greaterThan oleracea lessThan /i greaterThan L. was studied in aspirin plus pylorus ligation induced ulcer in albino rats. Eighteen healthy albino rats were divided into 3 groups of six animals each group. Group I (control) received 1ml/200 gram of 2% gum acacia, Group II (standard) received omeprazole 2 mg/kg body weight, Group III received the test drug i.e, the extract at 500 mg/kg body weight, and all groups received aspirin (200 mg/kg body weight). All the drugs were suspended in 2% gum acacia in distilled water and given orally at a uniform volume of 1ml/200 gram daily for 5 days before pyloric ligation. The anti-ulcer activity was evaluated by four parameters i.e, Ulcer Index, pepsin activity, free and total acidity, and gastric barrier mucus secretion. The extract shows significant anti-ulcer activity when compared with the control and comparable efficacy with the standard. This study shows that the aqueous extract of lessThan i greaterThan Portulaca oleracea lessThan /i greaterThan L. has significant anti-ulcer activity. BANYLLA SN, S. RITA , A. SUBHALAKSHMI DEVI U. DHARMARAJA MEETEI,KH. SANIA MONICA AND A. PFUZIA. Portulaca oleracea L., Anti-ulcer, Aspirin, Pyloric ligation. 576-580