10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) This article outlines the medicinal and biological significance of privileged scaffold, the 1,4-benzodiazepine. 1,4-benzodiazepine derivatives are showing very promising and excellent therapeutic effectiveness either as single heterocyclic derivatives or in fusion with the other cycles. An attempt is made in this article to highlight the medicinally active compounds which were reported to posses various biological activities. NAVJEET KAUR 1,4-Benzodiazepine, Privileged Scaffold, Medicinal significance, Biological significance. 318-337