A NEW APPROACH TO ANTI-HIV CHEMOTHERAPY DEVISED BY LINKING THE VITAL FRAGMENTS OF ACTIVE RT INHIBITORS SUCH AS ETRAVIRINE TO THE MOLECULAR FRAMEWORK OF ANTI-HIV PRONE PRIVILEGED NUCLEUS OF 1,4-BENZODIAZEPINE AS POSSIBLE SUBSTITUTE TO 'HAART'

10.22376/ijpbs.2019.10.1.p1-12

Volume 4 Issue 2 2013 (April - June) A NEW APPROACH TO ANTI-HIV CHEMOTHERAPY DEVISED BY LINKING THE VITAL FRAGMENTS OF ACTIVE RT INHIBITORS SUCH AS ETRAVIRINE TO THE MOLECULAR FRAMEWORK OF ANTI-HIV PRONE PRIVILEGED NUCLEUS OF 1,4-BENZODIAZEPINE AS POSSIBLE SUBSTITUTE TO 'HAART' In the anticipation of finding potential substitutes of highly active antiretroviral therapy [HAART], several molecular probes (9-12) have been developed by incorporating the vital fragments of RT inhibitor 'etravirine' to the anti-HIV prone privileged template of 1,4-benzodiazepine (2), on the premise that their presence in tandem in the same molecular framework could produce a positive impact in overcoming the problem arising due to the emergence of the multidrug resistant mutants of the virus. NAVJEET KAUR AIDS, etravirine, FDA, HAART, privileged heterocyclic scaffolds (1,4-benzodiazepine, pyrimidine), RT inhibitors. 309-317