10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) A series of novelalkyl-4-(4-(dialkylamino) phenyl)-1, 6-dimethyl-2-oxo/thioxo-1, 2, 3,4-tetrahydropyrimidine-5-carboxylates (4a-r) have been synthesized by Biginelli condensation with an efficient chloroindate(III) ionic liquid under mild reaction conditions in high yields. All the chemical structures of the title compounds were confirmed by elemental analysis and spectral data analysis. The newly synthesized compounds were evaluated their anti-microbial activity against lessThan i greaterThan Escherichia coli lessThan /i greaterThan , lessThan i greaterThan Staphylococcus aurous lessThan /i greaterThan and lessThan i greaterThan Candida albicans lessThan /i greaterThan and the lessThan i greaterThan in vitro lessThan /i greaterThan anti-tuberculosis activity also evaluated against lessThan i greaterThan Mycobacterium tuberculosis lessThan /i greaterThan H lessThan sub greaterThan 37 lessThan /sub greaterThan Rv (MTB). Among these compounds, 4m, 4o, 4n and 4pwere found to be the potent anti-tubercular compounds with minimum inhibition concentration (MIC).In addition, comparatively other compounds these compounds are also shown efficient biological activity against bacteria as well as fungi in order of 4m greaterThan 4o greaterThan 4n greaterThan 4p.From the results it is indicative that these analogues were found to possess a significant broad spectrum of anti-microbial and anti-tubercular potentiality. YEDDULA HARANADHA REDDY, CHINTHAPARTHI RADHA RANI, BHATNAGAR IRA, GANGIREDDY CHANDRA SEKHAR REDDY AND KALLURU SUBRAMANYAM REDDY 4-(Dialkyamino)benzaldehydes, Methyl/ethyl/propyl-3-oxobutanoate, 1-Methyl urea/thiourea, BMI.InCl4 ionic liquid, Biginelli condensation, Anti-microbial activity, anti-tubercular activity 296-308