10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) A series of 3-substituted aminophenyl-4-hydroxycoumarins 4a-h were synthesized lessThan i greaterThan via lessThan /i greaterThan Mannich reaction by using [BMIM]BF lessThan sub greaterThan 4 lessThan /sub greaterThan ionic liquid under microwave irradiation. Compounds were characterized by IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H NMR and mass spectroscopy. All the compounds were tested for their antibacterial activity against B. lessThan i greaterThan subtilis, lessThan /i greaterThan Bacillus. lessThan i greaterThan sp, lessThan /i greaterThan E. lessThan i greaterThan coli and lessThan /i greaterThan P. lessThan i greaterThan putida lessThan /i greaterThan . Most of the compounds showed moderate to good antibacterial activity. Docking studies of the synthesized compounds was done with the help of VLife MDS 3.5 software using GA docking method to study their observed activity. ONKARA.P, A.SUNIL KUMAR , S.KANAKARAJU ,B.PRASANNA,Y.PYDISETTY, AND G.V.P.CHANDRAMOULI 4-Hydroxy coumarin, Mannich base, Ionic liquid, Molecular docking, Antibacterial activity 263-270