10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) Ethanolic extracts of aerial parts of lessThan i greaterThan Solanum surattense lessThan /i greaterThan burn. (SS), were subjected to lessThan i greaterThan in vivo lessThan /i greaterThan study, by means of serum biochemical parameters and histopathological observations, in order to verify its traditional use in Hepatobiliary disorders. All groups of rabbits received a single dose of CCl lessThan sub greaterThan 4 lessThan /sub greaterThan subcutaneously on 7 lessThan sup greaterThan th lessThan /sup greaterThan day except group I which was served as normal control . Group II served as CCl lessThan sub greaterThan 4 lessThan /sub greaterThan control. While groups III, IV and V were served as silymarin control , test group 1 and test group 2 respectively. Results showed that CCl lessThan sub greaterThan 4 lessThan /sub greaterThan control group had raised levels of SGOT, SGPT and ALP significantly but TB level was not raised as compared to a normal control group. Pre-treatment with SS extract showed hepatoprotection as obvious by significant reinstatement of levels of SGOT, SGPT and ALP, while TB level was not changed significantly when compared with CCl lessThan sub greaterThan 4 lessThan /sub greaterThan control group. SS extract was more effective as compared to both silymarin and SS extracts because SS extract only significantly reduced SGOT level but unable to restore SGPT, ALP and TB levels. Histopathological examination of the liver tissue was further corroborated these results. Thus the outcome of the present study supports the conventional believes on hepatoprotective effects of lessThan i greaterThan Solanum surattense lessThan /i greaterThan . SOFIA ERAM , MAHMOOD AHMAD AND SHAFIA ARSHAD Solanum surattense, Hepatoprotection, Carbon tetrachloride, Serum biochemical parameters, Histopathology of liver. 207-214