10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) In recent years, a significant number of novel metabolites with potent pharmacological properties (antioxidant, antitumor, anti-HIV etc.) have been discovered from the marine organisms. lessThan i greaterThan Kappaphycus alvarezii lessThan /i greaterThan (Doty). Being an invasive in the Gulf of Mannar after 2000 AD, has high content of steroid, phenol etc., this work was the first report of its medical application. The present study investigated the medicinal valve of red alga lessThan i greaterThan Kappaphycus lessThan /i greaterThan lessThan i greaterThan alvarezii lessThan /i greaterThan using lessThan i greaterThan in vitro lessThan /i greaterThan studies. The algal methanol extract was screened for its antidiabetic evaluated by α- amylase; anti-inflammatory activity using hyaluronidase inhibition and cytotoxicity against the stannous chloride in lessThan i greaterThan E. coli lessThan /i greaterThan AB 1157. Chemical structures of the isolated compound from the thalli of lessThan i greaterThan K. alvarezii lessThan /i greaterThan were established by spectral techniques (UV, 125 H NMR). The methanol extract lessThan i greaterThan of K. alvareziis lessThan /i greaterThan showed potent α-amylase inhibition activity than anti-inflammatory activity. The screening results suggested that the algal can be processed further analysis using animal models. N. NAGARANI AND A. K. KUMARAGURU antidiabetic; anti-inflammatory; Kappaphycus; phytochemicals, proton NMR 921-929