10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) This review shares different mathematical models used to determine the kinetics of drug release from delivery systems. It consists of an overview of applied method for comparison like model dependent, model independent and statistical model. The mathematical modeling can finally help to optimize the design of a therapeutic device to yield a system with programmed release rate characteristics which is now a prerequisite for controlled release drug delivery system. For the ease of application of these models linear forms to plot the graphs were also discussed. This review also consists of various software programs available to describe the release kinetics from therapeutic device. HUSSAIN LOKHANDWALA, ASHWINI DESHPANDE AND SHIRISH DESHPANDE. Dissolution, drug release kinetic models, model dependent method, model independent method, statistical model, pairwise comparison. 728-737