10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Efforts have been made to prove the safety of the traditional Siddha medicine, Kasha Gulanthaga Mathirai. Effects of Kasha Gulanthaga Mathirai in model organisms were not reported till date. This paper appraises a detail study of physio-chemical properties, phytochemical constituents and heavy metal contents of the selected drug [KGM]. The ICPOES reveals that the main metals present in the tablet are Mercury and Arsenic. HRSEM analysis has been used to study particle size shape and distribution. The acute and long term toxicity studies were carried out in Swiss albino mice and Wister albino rats as per WHO guidelines. Histo pathological studies, hematological and biochemical parameters were done to find out any metal toxicity. Toxicity studies reveal the dose mentioned in siddha text kundriyalavu (130mg ) is the safety dose for human consumption. S.HARIHARAN, V.SUBA AND M.MURUGESAN Kasha Gulanthaga Mathirai, ICPOES studies, Swiss albino mice, Wister albino rats, Kundriyalavu 646-656