10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 1 2010 (January - March) A reverse phase HPLC method was developed for quantitative determination of Lercanidipine hydrochloride in tablets. The separation was achieved by using 250 Χ 4.6mm Wakosil C lessThan sub greaterThan 18 lessThan /sub greaterThan (5µm) column with a mixture of methanol: acetonitrile (70:30) as a mobile phase, at a flow rate of 1.0ml/min. The detection was carried out at 219nm, and the retention time was found to be 4.10min. Linearity was observed in the concentration range of 10-60µg/ml. The mean recoveries obtained for lercanidipine HCl ranged from 96.38 to 101.23 %. The LOD and LOQ was found to be 0.03µg/ml and 0.04µg/ml respectively. The developed method was found to be accurate, precise and rapid for analysis of Lercanidipine HCl in tablets. G. Mubeen, Mamta Pal and M. N. Vimala HPLC, Methanol, Acetonitrile, Lercanidipine Hydrochloride, Validation. -