10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 1 2013 (January - March) Methanol extracts of four seaweeds namely lessThan i greaterThan Padina tertastomatica, Sargassum wightii, Gracilaria edulis lessThan /i greaterThan and lessThan i greaterThan Caulerpa racemosa lessThan /i greaterThan were subjected to paw edema anti-inflammatory test. The extracts were injected into albino rats and the percentage inhibition of paw edema was calculated. Results revealed that all the seaweed extracts had equally good anti-inflammatory effects in the carageenan induced paw edema compared to those of standard drug (Diclofenac) (P lessThan 0.05). Maximum inhibition of 35.38% was found in the first hour after carageenen injection in lessThan i greaterThan Caulerpa lessThan /i greaterThan lessThan i greaterThan racemosa lessThan /i greaterThan extract. Similar percentage of inhibition (29.23 and 23.07) was also found in lessThan i greaterThan Padina lessThan /i greaterThan lessThan i greaterThan tertastomatica lessThan /i greaterThan and lessThan i greaterThan Sargassum lessThan /i greaterThan lessThan i greaterThan wightii, lessThan /i greaterThan after the first phase. The anti-inflammatory activity had its peak in the first phase and deceased as the hours increased. In lessThan i greaterThan Gracilaria edulis lessThan /i greaterThan anti-inflammatory activity showed a high level after third hour. D.RADHIKA, C.VEERABAHU AND R.PRIYA. Methanolic extract, anti-inflammation, Padina tertastomatica, Sargassum wightii, Gracilaria edulis and Caulerpa racemosa, paw edema. 39-44