10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 1 2010 (January - March) lessThan i greaterThan Trachyspermum ammi lessThan /i greaterThan fruit have traditionally been used in India as medicinal plant for the treatment of indigestion and dyspepsia and many other gastric disorders. In the present study ethanolic extract of lessThan i greaterThan Trachyspermum ammi lessThan /i greaterThan fruit was used for investigation of antiulcer activity by using pylorus ligation, as anti-secretary model and Indomethacin induced ulcer model, ethanol induced ulceration model, cold restraint stress induced ulcer model as cytoprotective model. Animals pretreated with ethanolic extract of lessThan i greaterThan Trachyspermum ammi lessThan /i greaterThan fruit at the dose 100mg/kg and 200mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggests that the extract at 100mg/kg and 200mg/kg showed significant protection (p lessThan 0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that lessThan i greaterThan Trachyspermum ammi lessThan /i greaterThan fruit extract shows significant antiulcer activity. S.Ramaswamy, S.Sengottuvelu, S.Haja Sherief, S.Jaikumar, R.Saravanan, C.Prasadkumar and T.Sivakumar Cytoprotective, Anti-secretory, Anti-ulcer and Trachyspermum ammi fruit. -