10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) Dental caries is a common disease that results in tooth loss or cavitations. Medicines available in market though effectively treat dental caries but not without imparting the harmful effects. Medicinal plants have proven to be an effective and safe alternative to synthetic medicines. In vitro antibacterial activity of leaves of lessThan i greaterThan Syzygium cumini lessThan /i greaterThan was studied against lessThan i greaterThan Streptococcus viridans, Streptococcus mutans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus lessThan /i greaterThan and lessThan i greaterThan Bacillus subtilis. lessThan /i greaterThan The aqueous, methanolic, hexane and ethyl acetate extract of leaves of lessThan i greaterThan S. cumini lessThan /i greaterThan exhibited the antimicrobial activity against dental caries causing strains. The largest zone of inhibition was obtained with the methanolic extract against lessThan i greaterThan E. coli lessThan /i greaterThan (20mm). Minimum Inhibitory Concentration (MIC) of extract was also determined against the selected microorganisms showing zone of inhibition ≥ 8mm.The study concluded that the leaves of lessThan i greaterThan S. cumini lessThan /i greaterThan possessed very good antibacterial activity against dental caries causing microorganisms and can be used as a potential source for making a phytomedicine that can be used to cure dental caries. Lubna Tahir, Safia Ahmed, Naqi Hussain, Irum Perveen And Salma Rahman Dental caries, antibacterial, methanol, hexane, ethyl acetate extract 1032-1038