10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) Curvacin A, a type of bacteriocin produced by lessThan i greaterThan Lactobacillus curvatus lessThan /i greaterThan LC05 has large spectrum of inhibition against human pathogenic, food spoilage microorganisms and many strains of lessThan i greaterThan Lactobacillus lessThan /i greaterThan were isolated as a test organisms. The Curvacin A inhibited lessThan i greaterThan Enterococcus faecalis lessThan /i greaterThan EF1 lessThan i greaterThan Escherichia lessThan /i greaterThan lessThan i greaterThan coli lessThan /i greaterThan NCTC 10418 but did not inhibit lessThan i greaterThan Candida albicans lessThan /i greaterThan ATCC 10321. The antibacterial activity of the strains were observed between mid lograthmic and stationary phase of growth. Larger quantity of Curvacin A was found produced when the medium is supplemented with yeast extract (3.0%) sodium chloride (1.0-2.0%), glucose (1%) and Tween 80 (0.5%). Supplementation of sodium acetate, magnesium sulphate, tri ammonium citrate and dipotassium phosphate had no effect on production of Curvacin A. A.Mohan Kumar And S.Arumugam Bacteriocin, Curvacin A, growth media, Lactobacillus curvatus LC05, antagonistic activity 427-432