10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) The rate of methicillin resistant Staphylococcus aureus (MRSA) infections has increased in recent years and clindamycin is considered to be one of the alternatives in these infections. In our study, a total of 337 Staphylococcus isolates from exudate samples in a tertiary care hospital were tested for inducible clindamycin resistance by D test according to the clinical laboratory standards institute (CLSI) guidelines. The inducible clindamycin resistance was higher 22% in hospital acquired MRSA isolates when compared to 9.8% in community acquired MRSA isolates. All methicillin resistant coagulase negative Staphylococci (MRCoNS) isolates were hospital acquired and they showed 20% inducible clindamycin resistance. Our study shows the increasing prevalence of inducible clindamycin resistance among Methicillin resistant Staphylococcal isolates and denotes that D test should be carried out routinely in all laboratories. Dr.R.Vasanthi , Dr. M.Jeya ,Mr.Karthick Clindamycin resistance, D test, Staphylococcus 372-380