10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) Objective: To determine the effect of Pantoprazole on oral glucose induced glycaemic changes and on basal blood glucose levels in normal albino rats. Methodology: Normal adult albino rats of either sex weighing between 150 – 200g were randomly divided into 2 groups(n=6); Control(distilled water-1ml/rat) and Test(Pantoprazole-6.5mg/kg BW) and the respective drug given orally for 3 days. They were fasted overnight at water before the 3 lessThan sup greaterThan rd lessThan /sup greaterThan day. On the 3 lessThan sup greaterThan rd lessThan /sup greaterThan day, 2 hours after the last drug dose , Oral glucose tolerance test(OGTT) was performed with glucose 0.6g/kg body weight(BW). Results: The average capillary blood glucose(CBG) of the Test(Pantoprazole) group was lower compared to the Control group at 60, 120 and 150 minutes progressively with maximum hypoglycaemia (CBG 22.9% ↓) at 150 minutes after glucose administration. Conclusion: Oral Pantoprazole given for 3 days has hypoglycaemic effect following oral glucose administration (which is progressive over time since glucose administration) by direct and indirect glucose induced insulin secretagogue effect. Ashwini V, Suresha Rn, Sushma Vn, Pushpa Vh, Yashoda C And Pragathi B Pantoprazole; oral glucose tolerance ; hypoglycaemia; Diabetes mellitus; glycaemic control 516-525