10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) Aims: To determine effect of nifedipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and magnitude of its effect on basal v/s glucose induced glycemic value. Methods: Normal adult albino rats of either sex weighing between 150 – 200g were randomly divided into 2 groups(n=6); Control(distilled water-1ml/rat) and Test(nifedipine-1.5mg/kg BW) and the respective drug given orally for 3 days. They were fasted overnight but with water before the 3 lessThan sup greaterThan rd lessThan /sup greaterThan day. On the 3 lessThan sup greaterThan rd lessThan /sup greaterThan day, 2 hours after the last drug dose , OGTT was performed with glucose 0.6g/kg BW. Results:The average CBG of the nifedipine group was higher compared to control group at 60, 120 and 150 minutes progressively with maximum hyperglycaemia (CBG 37.98% ) at 60 minutes after glucose administration. Conclusion: Nifedipine worsens glycaemic control in normal rats at all hours of glucose challenge. Extending this observation in human beings with overt diabetes mellitus/ high risk diabetics/ prediabetics, it is suggested to limit the use of nifedipine in situations unless absolutely necessary since it induces hyperglycaemia even in normoglycaemic rats by a postulated mechanism of inhibition of both basal and glucose induced insulin secretion significantly. Suresha Rn, Sushma Vn, Ashwini V, Kalabharathi Hl, Jayanthi Mk And Prathima CBG(capillary blood glucose), glycemic changes, nifedipine, oral glucose tolerance test 499-507