10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) A simple RP-HPLC method for the determination of olanzapine in pharmaceutical dosage forms. Numerous HPLC conditions were tested for determination of olanzapine. The best result was achieved by using Capcell pak C-18 (250×4.6mm) 5µm column and a mobile phase consisting of Acetonitrile: Water: Tri ethylamine (60:40:0.1 v/v/v), a flow rate of 1.0 ml/min with ultraviolet detection at 270nm. The retention time of the drug was 6.53 min. The method produced liner responses in the concentration range of 2 to 12µg/ml of olanzapine. The method was found to be applicable for determination of the drug in tablets. A.Rukmangada Rao, N.Delhi Raj And Jagadeesh Olanzapine, Estimation, RP-HPLC, Validation, Tablets. 267-272