10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) The present study was undertaken to investigate the diuretic effect of ethanolic seed extracts of lessThan i greaterThan Macrotyloma uniflorum lessThan /i greaterThan and lessThan i greaterThan Cucumis melo lessThan /i greaterThan in Albino rats. Ethanolic extracts of the seeds were administered to experimental rats orally at doses of 200mg/kg and 400mg/kg each p.o. Furosemide (5mg/kg) was used as a standard. The diuretic effects of the extracts were evaluated by measuring the Urine volume, Sodium, Potassium, Chloride and Bicarbonate contents. A significant Diuretic effect was observed from the experimental animals treated with extracts of lessThan i greaterThan Macrotyloma uniflorum lessThan /i greaterThan and lessThan i greaterThan Cucumis melo lessThan /i greaterThan individually compared to the control. Further, extract of lessThan i greaterThan Cucumis melo lessThan /i greaterThan (400mg/kg) showed more diuretic effect than standard. This might be the first formal report on diuretic effects of both extracts individually. The results, to some extent explains the use of lessThan i greaterThan Macrotyloma uniflorum and Cucumis lessThan /i greaterThan lessThan i greaterThan melo lessThan /i greaterThan as a cure for renal diseases in Indian traditional medical practice. lessThan sup greaterThan 1 lessThan /sup greaterThan K.Ravishankar And P.S.V.Vishnu Priya Diuretic activity, Macrotyloma uniflorum, Cucumis melo, Albino rats, natriuretic, Saluretic effect. 251-255