10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 3 2012 (July - September) The present study was aimed to determine the effect of ethanolic extract of lessThan i greaterThan Solanum torvum lessThan /i greaterThan (100 and 300 mg/kg; p.o. for 6 weeks) on isolated strip of ascending colon, Fundus and Vasdeferens in fructose (10%) fed rat. Chronic administration of lessThan i greaterThan S. torvum lessThan /i greaterThan extract (100, 300 mg/kg/day, p.o.) in fructose fed rats significantly (p lessThan 0.05) shifted the CCRC of Angiotensin (Ang-II, 10 ng/ml) and 5-Hydroxytryptamine (5-HT, 10 µg/ml) to the right with suppression of maxima as compared to CCRC of fructose fed rats on isolated ascending colon and fundus strip respectively. CCRC of Phenylephrine (PE, 10 µg/ml) using isolated Vas deferens was significantly (p lessThan 0.05) rise in rats cotreated with lessThan i greaterThan S. torvum lessThan /i greaterThan (100, 300 mg/kg/day, p.o.). The results clearly suggest that lessThan i greaterThan S. torvum lessThan /i greaterThan could block the Ang-II and 5-HT receptor and it also activate α lessThan sub greaterThan 1 lessThan /sub greaterThan -adrenergic pathway in this lessThan i greaterThan in-vitro lessThan /i greaterThan model study. Bs Jaiswal And M Mohan Angiotensin II, 5-Hydroxytryptamine, Solanum torvum, Fructose, CCRC 161-169