10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 2 2012 (April - June) Thyroid hormones influences the metabolism of all the substrates including minerals. A patient with thyroid dysfunction may also manifests the symptoms that are consequent upon the altered mineral levels. The study shows that hyper thyroidism increases the Ca lessThan sup greaterThan ++ lessThan /sup greaterThan level decreased by bone turn over. In hyperthyroidism increased tubular re absorption of Po lessThan sub greaterThan 4 lessThan /sub greaterThan lessThan sup greaterThan - lessThan /sup greaterThan affecting GFR, low clearance of Po lessThan sub greaterThan 4 lessThan /sub greaterThan -. Hyperthyroidism decreased renal blood flow will be leading to low clearance of Mg lessThan sup greaterThan 2+ lessThan /sup greaterThan & Zn lessThan sup greaterThan + lessThan /sup greaterThan from kidney. So low tubular excretion of Mg lessThan sup greaterThan 2+ lessThan /sup greaterThan & Zn lessThan sup greaterThan + lessThan /sup greaterThan will be prominent at plasma levels. The study was conducted over a period of six months. In this study, 30 subjects hyperthyroidism with euthyroidism were selected. Both males and females were included. Blood samples were collected for estimation of TSH, FT3,FT4, serum Ca, serum Po lessThan sub greaterThan 4 lessThan /sub greaterThan lessThan sup greaterThan - lessThan /sup greaterThan , serum Mg lessThan sup greaterThan 2+ lessThan /sup greaterThan & serum Zn lessThan sup greaterThan + lessThan /sup greaterThan . In Hyperthyroid patients, the serum levels of minerals Ca lessThan sup greaterThan + lessThan /sup greaterThan , Zn lessThan sup greaterThan + lessThan /sup greaterThan , Mg lessThan sup greaterThan 2+ lessThan /sup greaterThan (p lessThan 0.001) were significantly increased and PO lessThan sub greaterThan 4 lessThan /sub greaterThan (p lessThan 0.001) levels were significantly decreased compared to controls. Mineral status is observed in all the patients Ca lessThan sup greaterThan + lessThan /sup greaterThan levels are high because decreases bone turnover abating phosphorus levels negative influences on paratharmone and calcitonine, Zn lessThan sup greaterThan + lessThan /sup greaterThan & Mg lessThan sup greaterThan 2+ lessThan /sup greaterThan levels reflects the influences on GFR and increased clearance of these minerals Suneel B, J.N.Naidu And Aparna.R.R Thyroid stimulating hormone Zinc , Calcium, Magnesium , Glomuruli Filtration Rate 602-606