10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 2 2012 (April - June) Oil extracted from seeds of lessThan i greaterThan Schleichera trijuga lessThan /i greaterThan which is an unexplored plant from a local natural reserve forest in Orissa (India) was tested in order to explore a possible indigenous source of anti-fungal agent. Ripen fruits of lessThan i greaterThan S. trijuga lessThan /i greaterThan ("Kusum") were collected in its natural fruiting season and the oil fraction from sun dried seeds was extracted. This indigenous oil preparation (Kusum Oil) was tested for its anti-fungal activity against a total of 64 lessThan i greaterThan Candida albicans lessThan /i greaterThan isolates collected from infectious vitreous fluid of endophthalmitis patients. Its minimum inhibitory concentration (MIC) was estimated to be 333.33 ml/ml when tested against lessThan i greaterThan C. albicans lessThan /i greaterThan clinical isolates as well as the standard strain. Minimum detectable action time was found to be varying between 8 to 12 hours. The 'Kusum Oil' at its MIC was effective against 81.25% clinical isolates of lessThan i greaterThan C. lessThan /i greaterThan lessThan i greaterThan albicans lessThan /i greaterThan which was as efficient as Amphotericine-B and higher than Itraconazole (73.44%), Clotrimazole (71.875%), Nystatin (68.75%) and Fluconazole (59.375%). In our study 'Kusum Oil' was found to be an effective anti-mycotic agent against lessThan i greaterThan C. albicans lessThan /i greaterThan clinical isolates that expanded its medicinal utility possibly as an alternative source of anti-fungal agent. Guru C Patra, Priyadarshi S Sahu, Pritilata Panda, Santilata Sahoo, Santosh Mohapatra, Birendra Kumar Bindhani Kusum Oil, Schleichera, Candida albicans, Endophthalmitis 475-484