10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 2 2012 (April - June) Nicotine caused significant increase in the serum Cholesterol, Triglyceride, VLDL, LDL & significant reduction in HDL level. lessThan i greaterThan Premna integrifolia lessThan /i greaterThan & Atorvastatin treatment showed significant prevention in increased serum Cholesterol, Triglyceride, LDL as compared to Nicotine control (NC) group. While HDL level was significantly increased in treated & standard group as compared to Nicotine control (NC) group. Materials and methods used for research are as: male albino rats weighing 200-250 gm were divided into 4 groups viz. Normal control; Nicotine control (NC); Nicotine control (NC) & lessThan i greaterThan Premna integrifolia (Agnimantha) lessThan /i greaterThan (500 mg/ kg) treated; Nicotine control (NC) & Atorvastatin treated (standard control). Blood samples were collected after 7 days, for lipid estimation. From the above results we conclude that lessThan i greaterThan Premna integrifolia is lessThan /i greaterThan effective as an anti-hyperlipidemic agent. Manish J. Patel And Dr J.K. Patel hyperlipidaemia, Premna integrifolia 226-232