10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) Tapentadol is a centrally acting FDA approved analgesic for the treatment of moderate to severe acute pain with a dual mode of action as an agonist at the μ-opioid receptor and as a nor epinephrine reuptake inhibitor. It is used in chronic pain like, post operative, Neuropathic pain and End- stage degenerative joint disease. Oral dosages of 50 mg, 75 mg, or 100 mg /six hours tablets are available. Common side effects nausea, vomiting, dizziness, somnolence, headache, decreased seizure thresh hold, fatigue and also has dependence liability. B.Ramanath Royal Tapentadol, central analgesic, moderate to severe acute pain, less side effects 479-484