International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 1
2012 (January - March)
Design, Development And Characterization Ofmucoadhesive Tablets Of Atenolol
The aim of the present study was to formulate mucoadhesive tablets of atenolol using different bioadhesive polymers. The tablets were prepared using Sodiumcarboxymethylcellulose, Carbopol 940 and Hydroxypropylmethylcellulose as bioadhesive polymers to impart Mucoadhesion. Tablets were evaluated by different parameters such as weight uniformity, drug content, thickness, hardness, surface pH, swelling index mucoadhesive strength, wash out time and lessThan i greaterThan in vitro lessThan /i greaterThan drug release. No significant change was observed in physical appearance, drug content, surface pH, mucoadhesive strength, wash off time or lessThan i greaterThan in vitro lessThan /i greaterThan dissolution pattern after storage at 45 lessThan sup greaterThan o lessThan /sup greaterThan C/75% RH for three months.
Yash Paul, Sunil Kumar And Rahul Sehrawat
Atenolol, mucoadhesive drug delivery system, Sodium carboxymethylcellulose, hydroxypropylmethylcellulose, mucoadhesive strength
383-395