10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) A QSAR study has been attempted on the lessThan i greaterThan in vitro lessThan /i greaterThan antimycobacterial activities of N-Benzylsalicylamides and N-Benzylsalicylthioamides derivatives reported by Dolezal et al. against lessThan i greaterThan Mycobacterium avium lessThan /i greaterThan CNCTC My (330/88) using electrotopological state atom (E-state) parameter. The reported minimum inhibitory concentrations [MIC] of the compounds were determined after 21 days of incubation. Different statistical tools used in this communication are stepwise regression analysis and partial least squares analysis (PLS). All the developed models indicate the importance of connecting moiety methylcarboxamido / methylthiocarboxamido group between two substituted phenyl groups. From the PLS models it has been observed that hydroxyl group has negatively contributed towards activity. The models also indicate the Positive contribution of amino group towards activity. Based on internal validation (Q lessThan sup greaterThan 2 lessThan /sup greaterThan ), external validation (R lessThan sup greaterThan 2 lessThan /sup greaterThan lessThan sub greaterThan pred lessThan /sub greaterThan ) PLS analysis was found to be the best model (Q lessThan sup greaterThan 2 lessThan /sup greaterThan =0.624, R lessThan sup greaterThan 2 lessThan /sup greaterThan lessThan sub greaterThan pred lessThan /sub greaterThan =0.756). Supratim Ray QSAR, E-state, stepwise regression, PLS, N-Benzylsalicylamides, Benzylsalicylthioamides 151-160