10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) Adriamycin (ADR) is the most commonly used anthracyclin effective in malignant lymphomas and used for various cancers. The aim of the present investigation was to assess the protective effects of curcumin on adriamycin induced genotoxicity on the bone marrow chromosomes of Swiss albino mice. In the present experiment four group of Swiss albino animals were maintained. The experimental group was administered with 4 mg/kg of ADR in a single dose. The subsequent experimental group was administered with Phyllanthus Fruit Extract PFE 340 mg/kg/bw orally for two weeks and on sixteenth day ADR (4 mg/kg/bw) was given intraperitonially as a single dose. For each experimental group control, animals were maintained. Two days after the administration of the last dose, the animals were sacrificed and air dried metaphase preparations were made and processed for identification of chromosomal aberrations in somatic cells of mice. In animals treated with single dose of ADR, an increase was observed when compared with the values of control group. But when animals primed with PFE + ADR group, there was a decrease in the frequency of chromosomal aberrations. Thus the results clearly indicated the protective role of PFE on adriamycin induced genotoxic damage in somatic cells of mice K. Rudrama Devi And Kusum Lata Chamyal Somatic cells, Phyllanthus Fruit Extract, Adriamycin, Chromosomal aberrations. 133-140