10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) The acute toxicity study of Ceftriaxone+Sulbactam+Ethylenediaminetetraacetic acid was investigated to offer a solution for the treatment of bacterial infection caused by beta lactam resistant pathogens. A single intra venous injection at the dose levels of 50 mg/Kg, 250 mg/Kg and 500 mg/Kg body weight were administered to lessThan i greaterThan Swiss albino lessThan /i greaterThan mice lessThan i greaterThan lessThan /i greaterThan and lessThan i greaterThan Sprague dawely lessThan /i greaterThan rats (both male and female), where as control groups received normal saline. General behaviour , signs of toxicity, body weight, food and water consumption, and mortality were observed daily for 14 days. At the end of the study , hematological, biochemical, morphological and microscopic parameters were also determined. No toxicological meaningful difference, hazardous symptoms or death were observed in the acute toxicity test which indicates that a single i.v dose of Ceftraixone+sulbactam+EDTA combination at the dose levels of 50 mg/Kg, 250 mg/Kg and 500 mg/Kg body weight was not lethal in both mice and rats (male/female), and suggest a safe use in humans Manu Chaudhary And Krishnaraju V Acute toxicity, Mice, Rats,Ceftriaxone +Sulbactam+ EDTA 110-122