10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) Sindbis virus (SINV) is the prototype of Alphavirus genus, belonging to the family Togaviridae and has a positive-strand RNA genome. In humans, alphaviruses cause encephalitis, SINV causes arthritis and rash. The sudden onset of very high fever along with rash and severe arthralgia especially in the small joints of hands and toes are the characteristics of the disease. Currently, there are no vaccines or licensed therapies for SINV infection. Alphavirus replication and propagation is dependent on viral Non-Structural proteins. Hence NS proteins are chosen as an attractive target for the development of therapeutics. Due to the lack of crystal structure of nsp2 protease of SINV, in the present work we have performed multiple template modeling for the nsp2 protease of SINV with the crystal structures of the nsp2 protease from Chikungunya and Venezuelan Equine Encephalitis viruses as template. Next to target the nsp3, the macrodomain of Sindbis virus was modeled using the nsp3 macrodomain from Chikungunya Virus. Further molecular docking studies of the modeled structures were performed with Thieno-Pyrrole Derivatives as inhibitors using the commercial software Schrödinger, USA. Ramaiah Rajarajeshwari And Dr. P. Chitra Suresh Sindbis Virus nsp2 protease, nsp3 Macro domain, Thieno-pyrolle derivatives, Homology Modeling, Molecular Docking. 507-519