10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 1 2012 (January - March) The effects of pretreatment and co-administration of aqueous extract of lessThan i greaterThan Daucus carota lessThan /i greaterThan root on anti-tubercular drugs hepatotoxicity in rats were studied. Wistar albino rats were divided into six groups of three rats each. Groups 1 and 2 were normal and test control (administered with anti-tubercular drugs to induce hepatotoxicity) respectively. Groups 3 and 4 were pretreated with 100mg/kg bw and 200mg/kg bw of the extract for 28 days, then administered with anti-tubercular drugs isoniazid (INH) and rifampicin (RMP) at doses of 27mg/kg bw and 54mg/kg bw respectively for same duration. In groups 5 and 6, same doses of the extract and anti-tubercular drugs were administered concurrently for 28 days. Oral administration of the extract lessThan i greaterThan   lessThan /i greaterThan significantly (P Ë‚ 0.05) reduced serum ALT, AST, and ALP activities, and uBIL concentrations compared to the test control. The results suggested that aqueous extract of lessThan i greaterThan Daucus carota lessThan /i greaterThan might have had an hepatoprotective effect on anti-tubercular drugs hepatotoxicity in rats B. Bello And A. M. Wudil Daucus carota, hepatotoxicity, isoniazid, rifampicin, liver enzymes. 336-342