International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 4
2011 (October - December)
Analgesic Activity Of Methanolic Extract Of Jatropha Unicostata Balf, As Endemic Plant In Yemen
In the present study, we evaluate the analgesic activity of methanolic extract obtained from lessThan i greaterThan Jatropha unicostata balf lessThan /i greaterThan leaves lessThan i greaterThan , lessThan /i greaterThan using chemical and thermal models which will induce acute pain in mice and rats lessThan i greaterThan . lessThan /i greaterThan This study was carried out by using sex Swiss mice (20-30gm) and wistar male rats (200-250gm).The methanolic extract was prepared by using maceration at room temperature (25°) over the period of 48 hours. The effect of methanolic extract of lessThan i greaterThan Jatropha unicostata lessThan /i greaterThan was investigated for analgesic activity using acetic acid-induced abdominal writhings (Koster test) and Tail immersion method (Tail flick). The analgesic activity of methanolic extract of lessThan i greaterThan Jatropha unicostata lessThan /i greaterThan at the dose of (100 and 200 mg/kg, p.o.) showed significant (p≤0.001) in reducing abdominal writhings when compared with control and standard drug (Aspirin, 200 mg/kg, p.o.). However this extract at the dose 200 mg/kg, p.o. showed significant (p≤0.001) central analgesic action when compared with control and morphine (5 mg/kg, S.C.) as reference drug. In conclusion, the methanolic extract of lessThan i greaterThan Jatropha unicostata balf lessThan /i greaterThan produced significant analgesic activity in mice and rats.
Mosa’d Al-Sobarry, Ahmed Alwashli, Yahia Cherrah And Katim Alaoui
Medicinal plants, Jatropha unicostata balf, methanolic extract, acute toxicity, analgesic activity.
375-381