10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 4 2011 (October - December) A series of new nicotinyl-rhodanine derivatives were synthesized by condensing various chloronicotinaldehydes with rhodanine and substituted rhodanines. The lessThan i greaterThan in vitro lessThan /i greaterThan antitumor activity for these compounds was screened against MCF-7, A549 and HT29 human cancer cell lines. The results show that compounds lessThan b greaterThan 1 lessThan /b greaterThan , lessThan b greaterThan 3 lessThan /b greaterThan , lessThan b greaterThan 5 lessThan /b greaterThan , lessThan b greaterThan 7 lessThan /b greaterThan , lessThan b greaterThan 8 lessThan /b greaterThan and lessThan b greaterThan 9 lessThan /b greaterThan are more potent against MCF-7 cell lines; compounds lessThan b greaterThan 9 lessThan /b greaterThan and lessThan b greaterThan 11 lessThan /b greaterThan are more potent against A549 cell lines; compound lessThan b greaterThan 3 lessThan /b greaterThan is more potent against HT29 cell lines amongst the 14 nicotinyl-rhodanine compounds synthesized. The relationships between structure and antitumor activity were elucidated. Boddu Ananda Rao, Ravindra Singh Rajpoot, V. G. M. Naidu, Kolupula Srinivas, Sistla Ramakrishna, And Vaidya Jayathirtha Rao Rhodanine Derivatives, Nicotinaldehydes, Synthesis, Antitumor Activity, Structure-Activity Relations. 191-202