10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 4 2011 (October - December) Preeclampsia (PE) is a multisystem disorder characterized by hypertension, proteinuria and edema. Endothelial cell (EC) injury plays an important role in the pathogenesis of PE. The antioxidant enzyme SOD is a scavenger of superoxide anion and prevents oxidative damage of EC. Dysfunction of EC is associated with dyslipidemia due to oxidation of LDL, which is lowered by the enzyme PON-1. The aim of present study is to determine superoxide dismutase and paraoxonase-1 activity in preeclamptic women. In this study we found that serum SOD and PON-1 activity was decreased in preeclamptic women (3.614±0.539, 45.815±4.725) as compared to normal pregnant women (5.796±1.242, 65.012±6.318). But, SOD and PON-1 activity in between mild and severe PE women's were not-significant. Our observed results show decrease in the antioxidant SOD and PON-1 activity point towards their role in the pathogenesis of PE. Anil B. Bargale, Jayashree V. Ganu, Dhiraj J. Trivedi, Pramod S. Kamble And Rakesh Mudaraddi Preeclampsia, Endothelial cell dysfunction, Superoxide Dismutase, Paraoxonase-1 705-709