International Journal of Pharma and Bio Sciences
 
 
    ISSN 0975-6299
www.ijpbs.net


ORIGINAL RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 13 Issue 3, July-September, Pages:57-63

Ameliorative Effect of Tamarindus indica and Vitamin D Supplementation On Fluoride Induced Biochemical Parameters in Albino Rat

Shalini Yadav P.K. Singh, Prem Sagar and Harendra Nath Sharma
DOI: http://dx.doi.org/10.22376/Ijpbs.2022.13.3.b57-63
Abstract:

Fluoride water problem is very common in all areas of world including India. The deleterious effects of fluoride on bones causes fluorosis. This problem arises mainly due to gradual lowering of ground water level, which is merely responsible for degrading water quality. The hand pumps of many areas are restricted for use due to excess fluoride in their water. In a country like India, it is very tough to provide pure drinking water to all. Hence this study is designed to study the effect of fluoride on biochemical parameters in albino rats, the mammalian model.  The aim and objective of this study is to evaluate combination of two antioxidants viz. Tamarindus indica (rich source of vitamin C) and vitamin D against fluoride toxicity in mammals for which albino rat is used as model. Tamarindus have significant amount of antioxidants and vitamin D also have immunity and healing properties, hence this can be a reason behind their cumulative ameliorative effect against sodium fluoride intoxication. Further, the effect of fluoride can be minimized or ameliorated using some antioxidants and vitamins. For this purpose, the fluoride intoxicated rats were observed for possible amelioration by Tamarindus indica and vitamin D supplementation. The fluoride intoxication showed altered biochemical parameters like serum protein, SGOT, SGPT, ACP, ALP and LDH

Keywords: Fluoride, Tamarindus Indica, Vitamin D, Serum Glutamic-Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Acid Phosphatase, Alkaline Phosphatase, Lactate Dehydrogenase.
Full HTML:

REFERENCES

 

  1. Fluoride in drinking water, A scientific review of EPA;s standards. The National Academy of Sciences Reports, 2006.
  2. Singh PK, Feroz AD, Sheeba H, Khalil A, Samir AM. Beneficial effect of Tamarindus indica on the testes of albino rat after fluoride intoxication. Int J Pharma Bio Sci 2012; 3(3): (B) 487-493.
  3. Singh PK, Ahmad K. Beneficial effect of Tamarindus indica on the liver of albino rat after fluoride intoxication. Int J Pharma Bio Sci 206; 7(3):594-597.
  4. Singh PK, Mir SA. Beneficial effect of Tamarindus indica on the kidney of albino rat after fluoride intoxication. Int J Pharm Bio Sci 2016; 7(3): (B) 756-759.
  5. Ahmad S, Hiyasat A, Elbetieha AM, Darmani H. Reproductive toxic effect of ingestion of sodium fluoride in female rats. Fluoride 2000; 33: 279-284.
  6. Khandare AL, Kumar pU, Lakshmaiah N. Beneficial effect of tamarind ingestion on fluoride toxicity in dogs. Fluoride 2000; 33: 33-38.
  7. Ghanizadeh G, Babaei M, Naghii MR, Mofid M, Torkaman G, Hedayati M. The effect of supplementation of calcium, vitamin D, boron and increased fluoride intake on bone mechanism properties and metabolic hormones in rat. Toxicology and Industrial Health 2014; 30(3): 211-217.
  8. Dumas BT, Watson W and Biggs MG. Albumin standard and the measurement of serum albumin with Bromocresol green. Clin Chim Acta 1971; 31: 87-96.
  9. Reitman S and Frankel S. Estimation of SGOT and SGPT in serum. Am J Chem Path 1957; 28: 56-62.
  10. Kind PR, King E. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of clinical Pathology. 1954 Nov;7(4):322.
  11. King EJ, Jegatheesan KA. A method for the determination of tartrate-labile, prostatic acid phosphatase in serum. Journal of Clinical Pathology. 1959 Jan;12(1):85.
  12. Oba and Uriteni. Recommendation for the measurement of LDH in serum through UV kinetic method. Ann Biol Chem 1982; 40: 87.
  13. Fischer and Yates. Statistical tables for biological, agriculture and medical research, Longman, VIth edition. 1950 pp 146.
  14. Chouhan S, Lomash V, Flora SJS. Fluoride induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats. J Appl Toxicol 2010; 30: 63-73.
  15. Anfal D, Samir D. Study of fluoride induced haematological alterations and liver oxidative stress in rats. World Journal of Pharmacy and Pharmaceutical Sciences 2017; 6(5): 211-221.
  16. Sharma JD, Sharma MK, Agarwal P. Effect of fluoride contaminated drinking water in albino rats Rattus norvegicus. Asian J Exp Sci 2004; 18(1&2): 37-46.
  17. Chinoy NJ, Sharma A. Amelioration of fluoride toxicity by vitamins E and D in reproductive functions of male mice. Fluoride 1998; 31(4): 203-216.
  18. Samanta A, Bandyopadhyay B. Effect of fluoride toxicity on some clinical, biochemical and physiological aspects of albino rats. Int J Res Chem Env 2012; 2(1): 160-165.
  19. Sai AJ, Walters RW, Fang X, Gallagher JC. Relationship between vitamin D, parathyroid hormone and bone health. The Journal of Clinical Endocrinology and Metabolism 2011; 96: E436-E446.
  20. Guo XY, Sun GF, Sun YC. Oxidative stress from fluoride induced hepatotoxicity in rats. Fluoride 2003; 36: 25-29.
  21. Chaudhary S, Singh PK, Gupta AK, Singh AP. Combined effect of Tamarindus indica and Emblica officinalis on enzyme profile and lipid profile after fluoride intoxication in albino rats. J Ecophysiol Occup Hlth 2010; 10: 77-83.
  22. Barbier O, Laura AM, Luz MDR. Molecular mechanism of fluoride toxicity. Chemico Biological Interactions 2010; 188: 319-333.
  23. Khandare AL, Rao GS, Lakshmaiah N. Effect of tamarind ingestion on fluoride excretion in humans. Eur J Clin Nutr 2002; 56: 82-85.
  24. Khandare AL, Kumar PU, Shankar RG, Venkaiah K, Lakshmaiah N. Additional beneficial effect of tamarind ingestion over defluoridated water supply to adolescent boys in a fluorotic area. Nutrition 2004; 20: 433-436.
  25. Zhen X, XU Z, Li J, Wang M. Effects of fluorosis on lipid peroxidation and antioxidant system in young pigs. Fluoride 2005; 38:157-1.
  26. Bompart GJ, Prerof DS, Basconds JL. Rapid automated analysis of glutathione reductase, peroxidase and s-transferase activity. Clin Biochem 1990; 23:501-504.
  27. Rupal AV, Narasimhacharya AVRL. Ameliorative effect of tamarind leaf on fluoride induced metabolic alterations. Environ Health Prev Med 2012; 17: 484-493.

 

 

 

 

[Download PDF]
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy
Pharmaceutical Fields
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmaceutics
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Novel drug delivery system
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Nanotechnology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacognosy
© Copyright 2009-2015 IJPBS, India. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions
         Home I Contact I Terms & Conditions