Int J Pharm Bio Sci Volume 13 issue 2, April - June, Pages:9-15
Design and Evaluation of Mebeverine Hydrochloride Microspheres with Novel Timed Release Polymers
M Pradeep Kumar, G Suryanarayana Murthy, A Sreekanth, BV Ramana and Badithala Siva Sai Kiran.
DOI: 10.22376/Ijpbs.2022.13.2.p9-15
Abstract:
: Drugs having the shorter half life are needed to be administered frequently in order to maintain the required therapeutic concentrations. One of the strategies to overcome the frequent administration is by developing the controlled release formulations. Microspheres including the micro particles and microcapsules (having a core of the drug) of 1-1000 μm in diameter are one of the emerging controlled drug delivery systems that can eliminate the frequent drug administration. Hence, in the present study an effort was made to formulate microsphere of Mebeverine HCl by using different delayed-released polymers at different concentrations. Different formulations were prepared using guar gum and glutaraldehyde as delayed release polymers and evaluated for the properties like the effect of polymer concentrations on the microsphere formation, particle size, muco-adhesion etc. Also, the prepared microspheres were evaluated for flow properties along with the drug release rates. From the results, it was observed that higher concentrations of polymer resulted in better microsphere formation compared to low concentrations. Projection Microscopic images of optimized formulation showed that the microspheres have rough surface. In vitro drug release studies showed that the optimized formulation showed 96.26 percent Mebeverine HCl release at the end of 13 hours. Overall, it can be concluded that the preparation of Mebeverine HCl microspheres can eliminate the need for frequent administration thereby providing the better therapeutic compliance compared to the conventional dosage forms.
Jagan Mohan K, Venkatesham A. Pelletization techniques for oral drug delivery.Int J Pharm Sci Drug Res. 2009;1(2):63-70.
Ramu S, Ramakrishna G, Balaji M, Kondalarao K, Haranadhreddy S, pavankumar D. Multiple Unit Drug Delivery System: pelletization techniques. Am J Adv Drug Deliv. 2013;1(1):11-21.
SiyalHarshaBharkatiyaMeenakshi. Multiple Unit Particulate System: pelletization techniques: an overview. Int J Pharm Erudition. 2012;2(2):28-39.
Veena MC, Senthil Kumar SK, Parthiban S. Pelletization technique in drug delivery system-a review. Int J Pharm Devt Tech. 2013;3(1):13-22.
Hirjau M, Nicoara AC, Hirjau V, Lupuleasa D. Pelletization techniques used in pharmaceutical fields. Farma. 2011;4(3):4.
KibriaGolam, Ul-Jalil Reza. The effect of the ratio of two acrylic polymers on the in vitro release kinetics of ketoprofen from pellets prepared by extrusion and spheronisation technique. Pharm Sci. 2008;21(2):92-7.
Hansen Bryan Elizabeth R, Vinod Nair, Hoyt Forrest Vinod, Fischer David W, Dorward David WScanning electron microscopy. CurrProtocMicrobiol. 2012 6 (5): 1-5.
Palade GE. A study of fixation for electron microscopy. J Exp Med. 1952;95(3):285-98.
Vertzoni Maria, FotakiNikoletta, Kostewicz Edmund, Stippler Erika, Leuner Christian, NicolaidesEleftheria, Dressman Jennifer, Reppas Christos. Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects. J Pharm Pharmacol. 2004;56(4):453-62.
JantratidEkarat, Janssen Niels, Reppas Christos, Dressman Jennifer B. Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update. Pharm Res. 2008;25(7):1663-76.
KlancarUros, MarkunBostjan, Baumgartner Sasa, Legen Igor. A novel beads- based dissolution method for the in vitro evaluation of extended release HPMC matrix tablets and the correlation with the in vivo data. AAPS J. 2013 January;15(1):267-77.
Evans PR, Bak YT, Kellow JE. Mebeverine alters small bowel motility in irritable bowel syndrome. Aliment Pharmacol Ther. 1996;10(5):787-93.
Gilbody JS, Fletcher CP, Hughes IW, Kidman SP. Comparison of two different formulations of mebeverine hydrochloride in irritable bowel syndrome. Int J ClinPract. 2000;54(7):461-4.
Dickinson RG, Baker PV, Franklin ME, Hooper WD. Facile hydrolysis of mebeverine in vitro and in vivo: Negligible circulating concentrations of the drug after oral administration. J Pharm Sci. 1991;80(10):952-7.
Amidon S, Brown JE, Dave VS. Colon-targeted oral drug delivery systems: Design trends and approaches. AAPS Pharm Sci Tech. 2015;16(4):731-41.
Philip AK, Philip B. Colon targeted drug delivery systems: A review on primary and novel approaches. Oman Med J. 2010;25(2):79-87
Tehseen N, MdabdulhadiRao V. Design and characterization of twice daily mini-tablets formulation of pregabalin. Int J Pharm Pharm Sci. January 2013;5:168-75.
Berthold A, Cremer K, Kreuter J. Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. Journal of Controlled Release. 1996;39(1):17-25.
Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm. 2003;255(1-2):13-32.
Xiaoming Chen, KinamPark Hong Wen. Challenges and new technologies of oral controlled release.Oral Control Release Formulation Drug DelivTheorPract. 2011;16:257-77.
PankajOstwal P, PankajSalunkhe S, Mayur Jain S, Sumit Jain P. Development and evaluation for tablet-in capsule of nefedipine and atenolol. Int J Pharm Biol Sci. 2011;1(4):468-73.
MangeshBhad E, Shajahan Abdul, Sunil Jaiswal B, Anil Chandewar V, Jayesh Jain M, Dinesh Sakarkar M, Tablets MUPS, -Brief A [review]. Int J PharmTech Res. 2010;2(1):847-55.
RaghavendraRao NG, Abdul HadiMohd, Harsh Panchal. A Novel approach to sustained montelukast sodium release: differentially coated mini-tablets in HPMC capsules. Int J Pharm Biomed Sci. May 2011;2(2):90-7.
Bin Li, JiaBi, ChunLiZheng Zhu, Gong Wen. A novel system for three-pulse drug release based on ”tablets in capsule devices.” Int J Pharm. 2008 March 20;352(1-2):159-64.
Lopes Carla M, Lobo José Manuel Sousa, Pinto João F, Costa Paulo. Compressed mini-tablets as a biphasic delivery system.Int J Pharm. 2006;323(1-2):93-100.
26.Vanitha, Kasturi & Venkataswamy, M. & Niharika, Sanam & Alluri, Ramesh. (2018). Formulation Development and Evaluation of Mebeverine extended release Pellets. Asian Journal of Pharmacy and Technology. 8. 10.71-77.
Swathi, P. & Velrajan, G.. (2013). Formulation and evaluation of targeted and controlled release mebeverine hydrochloride microspheres. International Journal of Pharma and Bio Sciences. 4. P11-P20.
Hadi MA, Rao R. Novel technologies in formulations: an overview. World J Pharm Res. 2012 May 4;1(3):415-431.
El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. Drug Des Devel Ther. 2017;11:1081-1093.
Abdel-Hamid, Sameh & Abdel-Hady, Seham & El-Shamy, Abdel-Hamid & El-Dessouky, Hadir. (2007). A Novel Formulation for Mebeverine Hydrochloride. Drug development and industrial pharmacy. 33. 1078-89.
Mayur M, Avani F. Optimization and characterization of mebeverine hydrochloride loaded guar gum microspheres for irritable bowel syndrome. J Carbohydrate Polymers. 2011;86:536–545.
