This study was undertaken to evaluate the variations in thyroid profile, lipid profile and transaminase levels in overt hypothyroid patients, compared to healthy controls. Thirty hypothyroid patients, both male & female, in the age group of 20 to 50 years (study group) and 30 age & sex matched healthy subjects (control group) were enrolled in the study. We found significant increase in mean levels of total cholesterol, serum triglycerides, LDL-c, AST & TSH and significant decrease in T3 & T4 in study group compared to controls. There was no significant difference in HDL –c values between two groups. The ALT and VLDL-c values were near the upper limits of normal range in study group, while they were near the lower limit in control group, the difference being significant.