International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 2
2011 (April - June)
Wound Healing Effects Of Ageratum Conyzoides Linn.
The petroleum ether, chloroform, methanol and aqueous extracts of the leaves of lessThan i greaterThan Ageratum conyzoides lessThan /i greaterThan Linn. lessThan i greaterThan lessThan /i greaterThan (Asteraceae) were evaluated for their wound healing activity in rats using excision (normal and infected), incision and dead space wound models respectively. lessThan b greaterThan lessThan /b greaterThan The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase and histopathology of the granulation tissues. Nitrofurazone (0.2% w/w) in Simple ointment I. P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of lessThan i greaterThan A. conyzoides lessThan /i greaterThan lessThan b greaterThan lessThan i greaterThan lessThan /i greaterThan lessThan /b greaterThan showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plants also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of the leaves of lessThan b greaterThan lessThan i greaterThan A. conyzoides lessThan /i greaterThan lessThan strong greaterThan lessThan i greaterThan lessThan /i greaterThan lessThan /b greaterThan for wound healing activity as claimed in the folklore literature.
Gouri Kumar Dash And P. Narasimha Murthy
Ageratum conyzoides Linn., Wound healing, Excision wound model, Incision wound model, Dead space wound model.
369-382