International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 2
2011 (April - June)
Estimation Of Lornoxicam And Diacerein In Dosage Form By Simultaneous Equation And Q-Analysis Method Using UV Spectroscopic Technique
Two simple sensitive accurate uv spectroscopic methods were developed for the simultaneous estimation of diacerein and lornoxicam in pharmaceutical dosage form. In this communication simultaneous equation method and absorbance ratio method (Q value) were reported for the assay of both the drugs in the pharmaceutical dosage form. In simultaneous equation method the absorbance of the sample was measured at 341 nm and 398 nm respectively which was further applied for determining the concentration of the both the drugs. In absorbance ratio method (Q value) the absorbances were measured at wavelengths 341 nm and 398 nm and other at the isosbestic point i.e. 372 nm. The proposed methods were validated statistically for specificity, linearity, accuracy and precision. Recoveries of methods were carried out by standard addition method. The low values of standard deviation and percentage RSD indicated high precision of methods. These methods were successfully used for routine analysis of diacerein and lornoxicam in combination dosage form with good recoveries.
Rele R. V. And Warkar C. B.
Diacerein ,Lornoxicam,Simultaneous equation method, Absorbance ratio method
124-129