International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 9 Issue 2
2018 (April-June)
Recent progress on anti-cancer of amide appended heterocyclic and its possible therapeutic applications. A review drug progress for cancer therapeutics. (Funded work)
Cancer is caused by malignant neoplasm related to unregulated cell growth. Neoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery and neoangiogenesis, through that further confer cell survival improvement. There is a major unmet medical need for effective and well tolerated treatment options for cancer. The search now seeks to identify active biomolecules with multiple targets.This study has shown ambivalent results causing a prolonged over the value of drug and paving the way for the medicinal chemistry investigations of thiazole, pyridazine and pyrone analogues. Thiazole, pyridazine and pyrones nuclei show a broad spectrum of pharmaceutical applications. Thus, in this article, we have taken a step to review the evidences for cancer treatment, as well as to discuss the possible factors limiting the effectiveness of anti-cancer agents and to offer a recommendation for the future research of budding scientists on these therapies for the treatment of cancer has been taken.
YASSER HUSSEIN EISSA MOHAMMED, SHAUKATH ARA KHANUM
Anticancer; Malignant; Thiazole; Pyridazine; Neoplastic.
94-124