International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 1
2011 (January - March)
Hot melt coating techniques in sustained release formulation and evaluation of water soluble drug
Multiparticulate dosage forms are becoming an increasingly popular method for providing controlled release of drugs in the gastrointestinal (GI) tract as they minimize the risk of dose dumping. These multiparticulates usually consist of a drug entrapped in a sustaining matrix, or of a drug core over coated with a low permeability polymer film. Beads are one of the multiparticulate delivery systems and are prepared to obtain prolonged or controlled drug delivery, to improve bioavailability or stability and to target drug to specific sites. Waxes are one of the material which can be use to coat the drug in order to control the release. Hot melt coating technique defined as the application of fine layer of coating material in molten state over the substrate. Ethyl cellulose is a hydrophobic polymer used as a rate-controlling membrane to modulate the drug release from dosage forms with organic or aqueous coating techniques. The oral bioavailability of diclofenac potassium is around 60% with an excretion half-life between 1.1 and 1.8 h. It has an unpleasant taste and causes gastric irritation. As this drug is mainly absorbed from the gastrointestinal tract, an enteric coating provides sufficient taste masking without negatively affecting the availability of the drug. In the present study, preparation of sustained release formulation of water soluble drugs as diclofenac potassium in vitro, prediction of the release, & drug release pattern to match target release profile was investigated. This was prepared by non-aqueous solvent free technique using ethyl cellulose as rate controlling polymer. The developed sustained release formulation using,hot melt coating may be used in clinic for prolonged drug release in stomach, thereby improving the bioavailability & patient compliance.
P.L.Chandrikapure,K.J.Wadher,M.J.Umekar
hot melt coating, sustained release, cetyl alcohol, beeswax, multiparticulate system,
273-282