International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 7 Issue 4
2016 (October - December)
Effect of hespertin isolated from orange peels on Cisplatin-induced nephrotoxicity
The present study is to determine the effect of hespertin lessThan i greaterThan lessThan /i greaterThan isolated from orange peels on cisplatin-induced toxicity and Isolation of hespertin from the hesperdin by acid degradation to determine its effect on cisplatin – induced nephrotoxicity.In the present study, the hespertin (200 mg & 400 mg/ kg bd.wt) was examined for its protective effect against cisplatin induced renal injury in rats. Thirty healthy male and female albino rats (150- 200 g weight) were choosen and divided into five groups. Vehicle, cisplatin and hespertin were given according to the experimental design. After 8 days of treatment, urinary functional parameters were analysed. Histopathological characters were examined after scarifying and dissecting the rats. Cisplatin (6 mg/kg) alone significantly elevated serum markers level, increased urinary protein excretion, reduced urine to serum creatinine ratio and creatinine clearance. In curative regimen, the extract significantly reduced the elevated serum creatinine and urea levels. Renal antioxidant defense systems, such as superoxide dismutase, catalase, glutathione peroxides activities and reduced glutathione level, depleted by cisplatin therapy were restored to normal by treatment with the extract.The present investigation suggests the hespertin protective effect against cisplatin induced nephrotoxicity.
SPANDANA.U, SREEDEVI.A, HAVILAH ESTHER.S AND LAKSHMAIAH .P
Cisplatin; hespertin; nephrotoxicity; Creatinine; hesperdin.
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