International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 1 Issue 3
2010 (July - September)
Stress Proteins in Biology and Medicine: Evolution, Adaptation and Clinical Evaluation
Stress response is a universal phenomenon. The term, "stress", generally refers to any physical or psychological change that disrupts the organism's balance or homeostasis. Heat shock proteins (Hsps) are the proteins that are induced upon exposure of cells to stress conditions, hence, these proteins are also called as stress proteins. Several stressors including extra- and intracellular stresses induce Hsps in all the living forms. Induced Hsps help in cell survival through stabilizing several proteins of signal transduction, cell cycle, structural proteins and many more. Similar to tumors and certain pathophysiological conditions, Hsp expression in plant and other organisms may serve as a danger signal or diagnostic tool to identifying disease progression and stress prediction. This article reviews about Hsp's evolution , its genetic transcription in bacteria and yeast, gene transcription in mammals and plants,Hsp's in mammalian and plant development , in stress management , in disease management , as pharmacological targets .
Amere Subbarao Sreedhar,Perumal Vanathi,Khande Rao Paithankar
Stress response, Heat shock proteins, genetic transcription, pharmacological targets
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