International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 4
2015 (October - December)
A THERMODYNAMIC STUDY OF HOST-GUEST INCLUSION COMPLEX OF β-CYCLODEXTRIN AND LYSINE
The kinetics and oxidation of lysine by PMS in the presence of β-cyclodextrin was studied in acetic acid -sodium acetate buffer medium at 308 K. The rate constant n increased with increase in [Lysine]. In the addition of [beta cyclodextrin], the rate of the reaction increases. pH variation and solvent variation had no effect on the rate of the reaction. Thermodynamic parameters: free energy of activation (∆G lessThan sup greaterThan 0 lessThan /sup greaterThan ) enthalpy of activation (∆H lessThan sup greaterThan 0 lessThan /sup greaterThan ) and entropy of activation (∆S lessThan sup greaterThan 0 lessThan /sup greaterThan ) was calculated by studying the reactions at 303K, 308 K and 318K respectively. The positive value was obtained as enthalpy, entropy and free energy of activation. These entropy and enthalpy changes were favored through inclusions. The positive enthalpy values, positive entropic values are obtained, indicating that this inclusion was hydrophobic interaction. ∆Gâ—¦ obtained are also positive. It indicated that the inclusion process proceeded non-spontaneously at experimental temperature. The formation of inclusion complex was confirmed by UV-Visible absorption studies. The stability constant values of lysine are 3.7 L/mol. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 12.32 LM lessThan sup greaterThan -1 lessThan /sup greaterThan and 37.33M lessThan sup greaterThan -1 lessThan /sup greaterThan respectively. The method has been successfully applied to the determination of pharmaceutical formulation with good accuracy.
SHUNMUGAKANI AND DR. D.EASWARAMOORTHY
copper (II), glutamine, peroxomonosulphate (PMS), β-cyclodextrin (β-CD) catalyst, inclusion complex, kinetics
530-539